Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology
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چکیده
منابع مشابه
Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology*
Understanding the formation and propagation of aggregates of the Alzheimer disease-associated Tau protein in vivo is vital for the development of therapeutics for this devastating disorder. Using our recently developed live-cell aggregation sensor in neuron-like cells, we demonstrate that different variants of exogenous monomeric Tau, namely full-length Tau (hTau40) and the Tau-derived construc...
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1Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem 91120, Israel 2 Inserm U837, “Alzheimer & Tauopathies” Jean-Pierre Aubert Research Centre, University Lille-Nord de France, UDSL, Lille, France 3Departments of Neurology and Neuroscience & Cell Biology, George and Cynthia Mitchell Center for Neurodegenerativ...
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Tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with Alzheimer's disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks present in the brains of AD patients. Because NFTs are aberrant intracellular inclusions formed by hyperphosphorylated tau, it was initially...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.515445